The Translational Experimental Therapeutics Lab is strategically aligned with other medical school core facilities to provide investigators with data required to drive drug discovery and to facilitate translational medicine.
A critical component of translational medicine is the optimization of chemical compounds that have been identified by rational structure-based approaches or through screening protocols so that they can be used in clinical trials for treating disease. However this process presents a major hurdle in the drug discovery pipeline, particularly in an academic environment, since compounds identified in the initial phase of drug discovery invariably lack one or more biological properties, such as potency, oral bioavailability, selectivity or toxicity, that are essential for use as a diagnostic or therapeutic in humans.
The Translational Experimental Therapeutics Lab at Stony Brook is based in the SOM, and was established by the Office of Scientific Affairs in July of 2009. The laboratory provides a bridge between compound synthesis and inhibitor discovery in the Institute of Chemical Biology & Drug Discovery, and clinical research in the SOM. It has been established to facilitate the process of moving compounds through the drug discovery pipeline by providing in vivo data on compound absorption, distribution, metabolism, excretion and toxicity (ADME/T). The Translational Experimental Therapeutics Lab thus seeks to overcome a major hurdle in academic drug discovery pipeline by providing a mechanism for integrating chemical synthesis with methods to assess compound ADME/T.
Pharmacokinetics in the Translational Experimental Therapeutics Lab
One of the main activities of the Translational Experimental Therapeutics Lab is to provide pharmacokinetic (PK) data on lead compound series. This component of the laboratory is supported through the vertical integration of the Division of Laboratory Animal Research and the Mass Spectrometry Facility which is equipped with a triple quad mass spectrometer for accurate compound quantitation. The PK service is available to both internal and external users.
Peter Tonge, Professor
Director, Translational Experimental Therapeutics Lab
Phone: (631) 632-7907
Glen Itzkowitz, Assistant Dean
Office of Scientific Affairs, School of Medicine
HSC Level-4, Room 172
Phone: (631) 444-1217