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Office of Scientific Affairs
School of Medicine

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Updated: Sept 21, 2010

SUNY Stony Brook School of Medicine Research Core Facilities are coordinated under the Office of Scientific Affairs. The goal of these facilities is to provide commonly used technologies to the campus, and thus facilitate the research processes. The facilities and a short description for each facility are listed below:

Bioinformatics Facility Bioinformatics Facility
The Bioinforamtics Facility provides a strong combination of life science principles and computer skills. The facility is committed to helping researchers handle information in a more efficient way. Services include:
  • High Throughput Genomics, Proteomics, Expression Data Analysis
  • General Bioinformatics Consultation
  • Grant Proposal Assistance
  • Custom Programming
  • Experiment Design
  • Web Services
Biostatistical Consulting Core Biostatistical Consulting Core
The Biostatistical Consulting Core (BCC) within Department of Preventive Medicine provides expert assistance and collaborations to researchers at every stage of a research project. Services include:
  • Study design
  • Grant proposal writing
  • Data analysis and management
  • Statistical reporting and interpretation
Cell Culture/Hybridoma Facility Cell Culture/Hybridoma Facility
Located in the Department of Molecular Genetics and Microbiology for over 20 years, Room 233 Life Sciences Building, provides cell culture services for University-affiliated and private-sector researchers on a fee-for-service basis. Services include:
  • Providing monolayer, suspension and hybridoma cultures from a large cell bank on-site or from investigators' stock
  • Mycoplasma testing, PCR method
  • Custom hybridoma development
  • Large-scale monoclonal antibody production and quantitation
  • Selling media, sera and cell culture supplements at reduced cost to University investigators
Clinical Trials Services Clinical Trials Services
A parternership between Industry and Stony Brook University through a variety of mechanisms. These collaborations include:
  • Match and recruit clinical trials to individual investigators
  • Assist in the recruitment of subjects for approved clinical trials
  • Establish inter investigator collaboration by matching investigator expertise to anotherís areas of research interest
  • Facilitate and advise investigators of the procedures, forms and system structure needed for university approvals for grants and clinical trial protocols
Division of Laboratory Animal Resources (DLAR) Division of Laboratory Animal Resources (DLAR)
The Division of Laboratory Animal Resources (DLAR) at Stony Brook University is fully committed to the judicious, humane use of animals in research and teaching. The Division supports all SBU animal related research through the provision of laboratory animal management and veterinary medical care and assures institutional compliance with all federal, state and local regulations and policies. Services include:
  • Animal procurement
  • Animal husbandry
  • Veterinary care including health surveillance, preventative medicine programs, animal quarantine, personnel training and special technical support
  • Maintenance of animal facilities and equipment
DNA Microarray Facility DNA Microarray Facility
A full service Affymetrix Genechip core facility. Expression arrays for Human, Murine, Rat, Drosophila, C. elegans, Arabidopsis, Yeast and E. coli, are available. Services include:
  • Complete sample preparation
  • Hybridization
  • Preliminary data analysis
DNA Sequencing Facility DNA Sequencing Facility
The DNA Sequencing Facility has been actively serving researchers from more than 100 labs at Stony Brook and neighboring institutions for the past few years. In the year 2002, the facility processes about 100 sequencing samples per day. Services include:
  • Complete DNA sequencing (PCR reaction plus electrophoresis)
  • Electrophoresis-only DNA sequencing
  • Real-Time PCR service
  • Automatic plasmid mini-preparation
Flow Cytometry Facility Flow Cytometry Facility
The laboratory is equipped with a Becton Dickinson FACSCAN analyzer, two FACS Calibers, and a three laser FACS VANTAGE Cell Sorter with full supportive equipment. Five full time technologists combined with over 40 years experience in Flow Cytometry. Service include:
  • FACS analysis
  • Cell sorting
  • Cell labeling and preparation
  • Computer data analysis
  • Free consultation to discuss the application of flow cytometry to your projects
  • Free review of data representation for publication
Genomics Core Facility Genomics Core Facility
The newly created Genomics Core Facility is charged with the mission of facilitating all aspects of research related to genetics/genomics at Stony Brook University. The facility aims to provide scientists at Stony Brook with the tools required to maximize their research. In the longer term, it is hoped that this facility will pave the way for Stony Brook to become a center of excellence in translational medicine, with particular emphasis on human genetics. Services include:
  • aCGH - microarray-based comparative genomic hybridization
  • Mutation screening service using melt analysis
  • Multiplex ligation-dependent probe amplification (MLPA)
  • Pyrosequencing
  • Consultation service
Micro CT Facility Micro CT Facility
The Micro CT Facility is equipped with VivaCT75, a high-resolution microCT scanner that reconstructs 2D images into a 3D tommography to describe the morphology and micro-architecture of hard/soft tissues and fluids in small animal models.
  • High quality 3D images in vivo and ex vivo
  • Volumetric and density analysis of multiple tissues
  • Evaluation of visceral and subcutaneous adipose tissue
  • Micro-architectural analysis of bone
  • Shape, size, and density evaluation of tumors
Microscopy Imaging Center Microscopy Imaging Center
The Microscopy Imaging Center is equipped with Multiphoton Confocal Microscope and Digital Transmission Electron Microscope. Services include:
  • 2-Photon Confocal User Operated
  • TEM Technician Operated
  • 2-Photon Confocal Tech Operated
  • Sample Prep TEM
  • MicroTEM Tech Operated
  • MicroTEM Sample Prep
  • InVivo 2-Photon (available soon)
Molecular Cloning Facility Molecular Cloning Service
The Molecular Cloning Service Facility maintains a large collection of vectors including bacteria, yeast, baculovirus, adenovirus, mammalian tagged expression, fluorescent protein fusion, in vitro transcription / translation vectors. Service include:
  • Maintain vector information
  • Performs sub-cloning or site-directed mutagenesis
  • Train / assist with advanced techniques, such as knock-out vectors, vector for stable inducible cell lines, RNAi
Proteomics Center (CASM) Proteomics Center
Formerly the Center for the Analysis and Synthesis of Macromolecules (CASM). The Proteomics Center is equipped with state-of-the-art technologies, including the latest Thermo LTQ-Orbitrap XL ETD LC/MS/MS System. Services include:
  • Protein identification
  • Post-translational modification identification
  • 1D/2D gel electrophoresis
  • Mass Spectrometry
  • 1D/2D LC/MS/MS analysis
  • Biacore (walk-up instrument)
  • HPLC
Translational Experimental Therapeutics Lab Translational Experimental Therapeutics Lab
The Translational Experimental Therapeutics Lab is strategically aligned with other medical school core facilities to provide investigators with data required to drive drug discovery and to facilitate translational medicine.
  • Provide pharmacokinetic (PK) data on lead compound series